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The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution

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Item Type:Review
Title:The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution
Creators Name:Taylor, D.M. and Aronow, B.J. and Tan, K. and Bernt, K. and Salomonis, N. and Greene, C.S. and Frolova, A. and Henrickson, S.E. and Wells, A. and Pei, L. and Jaiswal, J.K. and Whitsett, J. and Hamilton, K.E. and MacParland, S.A. and Kelsen, J. and Heuckeroth, R.O. and Potter, S.S. and Vella, L.A. and Terry, N.A. and Ghanem, L.R. and Kennedy, B.C. and Helbig, I. and Sullivan, K.E. and Castelo-Soccio, L. and Kreigstein, A. and Herse, F. and Nawijn, M.C. and Koppelman, G.H. and Haendel, M. and Harris, N.L. and Rokita, J.L. and Zhang, Y. and Regev, A. and Rozenblatt-Rosen, O. and Rood, J.E. and Tickle, T.L and Vento-Tormo, R. and Alimohamed, S. and Lek, M. and Mar, J.C. and Loomes, K.M. and Barrett, D.M. and Uapinyoying, P. and Beggs, A.H. and Agrawal, P.B. and Chen, Y.W. and Muir, A.B. and Garmire, L.X. and Snapper, S.B. and Nazarian, J. and Seeholzer, S.H. and Fazelinia, H. and Singh, L.N. and Faryabi, R.B. and Raman, P. and Dawany, N. and Xie, H.M. and Devkota, B. and Diskin, S.J. and Anderson, S.A. and Rappaport, E.F. and Peranteau, W. and Wikenheiser-Brokamp, K.A. and Teichmann, S. and Wallace, D. and Peng, T. and Ding, Y.Y. and Kim, M.S. and Xing, Y. and Kong, S.W. and Bönnemann, C.G. and Mandl, K.D. and White, P.S.
Abstract:Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.
Keywords:Developmental Gene Expression Regulation, Embryonic Development, Gene Expression Profiling, Gene Regulatory Networks, Pediatrics, Single-Cell Analysis, Tissue Distribution
Source:Developmental Cell
ISSN:1534-5807
Publisher:Cell Press (U.S.A.)
Volume:49
Number:1
Page Range:10-29
Date:8 April 2019
Official Publication:https://doi.org/10.1016/j.devcel.2019.03.001
PubMed:View item in PubMed

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