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Extensive transmission of microbes along the gastrointestinal tract

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Item Type:Article
Title:Extensive transmission of microbes along the gastrointestinal tract
Creators Name:Schmidt, T.S.B. and Hayward, M.R. and Coelho, L.P. and Li, S.S. and Costea, P.I. and Voigt, A.Y. and Wirbel, J. and Maistrenko, O.M. and Alves, R.J.C. and Bergsten, E. and de Beaufort, C. and Sobhani, I. and Heintz-Buschart, A. and Sunagawa, S. and Zeller, G. and Wilmes, P. and Bork, P.
Abstract:The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral species to the intestine is considered a rare aberrant event, and a hallmark of disease. By studying salivary and fecal microbial strain populations of 310 species in 470 individuals from five countries, we found that transmission to, and subsequent colonization of, the large intestine by oral microbes is common and extensive among healthy individuals. We found evidence for a vast majority of oral species to be transferable, with increased levels of transmission in colorectal cancer and rheumatoid arthritis patients and, more generally, for species described as opportunistic pathogens. This establishes the oral cavity as an endogenous reservoir for gut microbial strains, and oral-fecal transmission as an important process that shapes the gastrointestinal microbiome in health and disease.
Source:eLife
ISSN:2050-084X
Publisher:eLife Sciences Publications (U.K.)
Volume:8
Page Range:e42693
Date:12 February 2019
Official Publication:https://doi.org/10.7554/eLife.42693.001
PubMed:View item in PubMed

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