Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Leptomeningeal and intraparenchymal blood barrier disruption in a MOG-IgG-positive patient

[img] PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB

Item Type:Article
Title:Leptomeningeal and intraparenchymal blood barrier disruption in a MOG-IgG-positive patient
Creators Name:Mohseni, S.H. and Skejoe, H.P.B. and Wuerfel, J. and Paul, F. and Reindl, M. and Jarius, S. and Asgari, N.
Abstract:BACKGROUND: Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis. Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis. FINDINGS: We report the case of a 30-year-old previously healthy woman presenting with longitudinally extensive transverse myelitis and tetraparesis, in whom both the leptomeningeal barrier and the blood-brain barrier (BBB) were altered, as demonstrated by gadolinium-enhanced MRI during relapse. Blood samples taken at onset and four years later were retrospectively found positive for MOG-IgG. CONCLUSION: Our findings demonstrate that spinal leptomeningeal enhancement (LME) can occur in MOG-IgG-positive encephalomyelitis (EM) and may accompany intraparenchymal BBB breakdown.
Source:Case Reports in Neurological Medicine
ISSN:2090-6676
Publisher:Hindawi (U.K.)
Volume:2018
Page Range:1365175
Date:9 December 2018
Official Publication:https://doi.org/10.1155/2018/1365175
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library