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Leptomeningeal and intraparenchymal blood barrier disruption in a MOG-IgG-positive patient

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Item Type:Article
Title:Leptomeningeal and intraparenchymal blood barrier disruption in a MOG-IgG-positive patient
Creators Name:Mohseni, S.H. and Skejoe, H.P.B. and Wuerfel, J. and Paul, F. and Reindl, M. and Jarius, S. and Asgari, N.
Abstract:BACKGROUND: Recently, pathogenic serum immunoglobulin G (IgG) autoantibodies to myelin oligodendrocyte glycoprotein (MOG) have been detected in a subgroup of patients with central nervous system (CNS) demyelination, including in patients with myelitis. Relatively little is known so far about leptomeningeal involvement in MOG-IgG-positive myelitis. FINDINGS: We report the case of a 30-year-old previously healthy woman presenting with longitudinally extensive transverse myelitis and tetraparesis, in whom both the leptomeningeal barrier and the blood-brain barrier (BBB) were altered, as demonstrated by gadolinium-enhanced MRI during relapse. Blood samples taken at onset and four years later were retrospectively found positive for MOG-IgG. CONCLUSION: Our findings demonstrate that spinal leptomeningeal enhancement (LME) can occur in MOG-IgG-positive encephalomyelitis (EM) and may accompany intraparenchymal BBB breakdown.
Source:Case Reports in Neurological Medicine
Page Range:1365175
Date:9 December 2018
Official Publication:https://doi.org/10.1155/2018/1365175
PubMed:View item in PubMed

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