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Novel strategy for the preparation of 3-perfluoroalkylated-2 H-indazole derivatives

Item Type:Article
Title:Novel strategy for the preparation of 3-perfluoroalkylated-2 H-indazole derivatives
Creators Name:Bel Abed, H. and Weißing, N. and Schoene, J. and Paulus, J. and Sewald, N. and Nazaré, M.
Abstract:A simple and novel methodology for the synthesis of 3-perfluoroalkylated-2H-indazole derivatives has been elaborated. The perfluoroalkylation of readily available 2-nitrobenzaldimines bearing electron donating groups was performed using the Ruppert-Prakash reagent and its analogues to afford α-difluoromethylated, α-trifluoromethylated and α-pentafluoroethylated benzylamines. A final reductive cyclization mediated by SnCl(2)·2H(2)O led to 2H-indazoles containing perfluoroalkyl groups via the generation of a new NN bond in moderate to good yields.
Keywords:2H-Indazole, Perfluoroalkylation, N-N Bond Formation, Ruppert-Prakash Reagent, Reductive Cyclization
Source:Tetrahedron Letters
ISSN:0040-4039
Publisher:Elsevier (U.K.)
Volume:59
Number:19
Page Range:1813-1815
Date:9 May 2018
Official Publication:https://doi.org/10.1016/j.tetlet.2018.03.051

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