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The dynamic nature of senescence in cancer

Item Type:Review
Title:The dynamic nature of senescence in cancer
Creators Name:Lee, S. and Schmitt, C.A.
Abstract:Cellular senescence is implicated in physiological and pathological processes spanning development, wound healing, age-related decline in organ functions and cancer. Here, we discuss cell-autonomous and non-cell-autonomous properties of senescence in the context of tumour formation and anticancer therapy, and characterize these properties, such as reprogramming into stemness, tissue remodelling and immune crosstalk, as far more dynamic than suggested by the common view of senescence as an irreversible, static condition.
Keywords:Biological Models, Cell Communication, Cell Cycle Checkpoints, Cellular Reprogramming, Cellular Senescence, Neoplasms, Neoplastic Cell Transformation, Tumor Microenvironment, Animals
Source:Nature Cell Biology
ISSN:1465-7392
Publisher:Nature Publishing Group (U.K.)
Volume:21
Number:1
Page Range:94-101
Date:January 2019
Official Publication:https://doi.org/10.1038/s41556-018-0249-2
PubMed:View item in PubMed

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