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The influence of capsaicin on the integrity of microvascular endothelial cell monolayers

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Item Type:Article
Title:The influence of capsaicin on the integrity of microvascular endothelial cell monolayers
Creators Name:Kaiser, M. and Burek, M. and Britz, S. and Lankamp, F. and Ketelhut, S. and Kemper, B. and Förster, C. and Gorzelanny, C. and Goycoolea, F.M.
Abstract:Microvascular endothelial cells are an essential part of many biological barriers, such as the blood-brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.
Keywords:Tight Junctions, Capsaicin, Endothelial Cells, Animals, Mice
Source:International Journal of Molecular Sciences
ISSN:1422-0067
Publisher:MDPI (Switzerland)
Volume:20
Number:1
Page Range:122
Date:30 December 2018
Official Publication:https://doi.org/10.3390/ijms20010122
PubMed:View item in PubMed

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