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Experimental validation of a preclinical SPECT/MR insert

Item Type:Article
Title:Experimental validation of a preclinical SPECT/MR insert
Creators Name:Carminati, M. and Occhipinti, M. and Baratelli, F. M. and Montagnani, G. L. and Nagy, K. and Nyitrai, Z. and Nagy, A. and Czeller, M. and Kühne, A. and Niendorf, T. and Mathe, D. and Belloli, S. and Valtorta, S. and Moresco, R. M. and Falini, A. and Iadanza, A. and Ottobrini, L. and Fiorini, C.
Abstract:The experimental characterization of a SiPM-based 10-module SPECT gamma imager suitable for insertion and operation inside unmodified MR scanners for simultaneous (and potentially multi-tracer) preclinical imaging is presented. The design challenges, here fulfilled, such as compactness while granting proper cooling, mutual compatibility and resilience to high (3-7 T) magnetic fields inside the bore, suitable energetic (better than 14% at 140 keV) and spatial resolution (better than 1 mm) are discussed. The carefully optimized detection module, featuring a 5 × 5 cm 2 CsI(Tl) scintillator coupled to arrays of SiPM conditioned by a 36-channel ASIC, and the digital daisy chain infrastructure are the basis for the realization of a larger (20-module ring) clinical insert. Moreover, planar image reconstruction based on advanced statistical approaches such as maximum likelihood and iteratively estimated light response function is reported.
Source:IEEE Nuclear Science Symposium and Medical Imaging Conference
Title of Book:2017 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
Publisher:IEEE (U.S.A.)
Page Range:18264750
Official Publication:https://doi.org/10.1109/NSSMIC.2017.8532678

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