Helmholtz Gemeinschaft


Models of polymer physics for the architecture of the cell nucleus

Item Type:Article
Title:Models of polymer physics for the architecture of the cell nucleus
Creators Name:Esposito, A. and Annunziatella, C. and Bianco, S. and Chiariello, A.M. and Fiorillo, L. and Nicodemi, M.
Abstract:The depth and complexity of data now available on chromosome 3D architecture, derived by new technologies such as Hi-C, have triggered the development of models based on polymer physics to explain the observed patterns and the underlying molecular folding mechanisms. Here, we give an overview of some of the ideas and models from physics introduced to date, along with their progresses and limitations in the description of experimental data. In particular, we focus on the Strings&Binders and the Loop Extrusion model of chromatin architecture.
Keywords:Chromatin, Computational Biology, Polymer Physics
Source:Wiley Interdisciplinary Reviews Systems Biology and Medicine
Page Range:e1444
Date:July 2019
Additional Information:This article will also be available in Open Access at PubMed Central with a delayed release (embargo) on July 1, 2020.
Official Publication:https://doi.org/10.1002/wsbm.1444
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library