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Light-microscopy methods in C. elegans research

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Item Type:Review
Title:Light-microscopy methods in C. elegans research
Creators Name:Breimann, L. and Preusser, F. and Preibisch, S.
Abstract:Ever since Caenorhabditis elegans was introduced as a model system it has been tightly linked to microscopy, which has led to significant advances in understanding biology over the last decades. Developing new technologies therefore is an essential part in the endeavor to gain further mechanistic insights into developmental biology. This review will discuss state-of-the-art developments in quantitative light microscopy in the context of C. elegans research as well as the impact these technologies have on the field. We will highlight future developments that currently promise to revolutionize biological research by combining sequencing-based single-cell technologies with high-resolution quantitative imaging.
Keywords:Developmental Biology, Microscopy, Animals, Caenorhabditis elegans
Source:Current Opinion in Systems Biology
Publisher:Elsevier (The Netherlands)
Page Range:82-92
Date:February 2019
Official Publication:https://doi.org/10.1016/j.coisb.2018.11.004

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