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Mapping the MHC class I spliced immunopeptidome of cancer cells

Item Type:Article
Title:Mapping the MHC class I spliced immunopeptidome of cancer cells
Creators Name:Liepe, J. and Sidney, J. and Lorenz, F.K.M. and Sette, A. and Mishto, M.
Abstract:Anti-cancer immunotherapies demand optimal epitope targets, which could include proteasome-generated spliced peptides if tumor cells were to present them. Here, we show that spliced peptides are widely presented by MHC class I molecules of colon and breast carcinoma cell lines. The peptides derive from hot spots within antigens and enlarge the antigen coverage. Spliced peptides also represent a large number of antigens that would otherwise be neglected by patrolling T cells. These antigens tend to be long, hydrophobic, and basic. Thus, spliced peptides can be a key to identifying targets in an enlarged pool of antigens associated with cancer.
Keywords:Proteasome, Peptide Splicing, Adaptive T Cell Therapy Targets, Antigen Presentation In Tumors, Epitopes
Source:Cancer Immunology Research
ISSN:2326-6066
Publisher:American Association for Cancer Research (U.S.A.)
Volume:7
Number:1
Page Range:62-76
Date:January 2019
Official Publication:https://doi.org/10.1158/2326-6066.CIR-18-0424
PubMed:View item in PubMed

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