Mapping the MHC class I spliced immunopeptidome of cancer cells

Item Type:	Article
Title:	Mapping the MHC class I spliced immunopeptidome of cancer cells
Creators Name:	Liepe, J. and Sidney, J. and Lorenz, F.K.M. and Sette, A. and Mishto, M.
Abstract:	Anti-cancer immunotherapies demand optimal epitope targets, which could include proteasome-generated spliced peptides if tumor cells were to present them. Here, we show that spliced peptides are widely presented by MHC class I molecules of colon and breast carcinoma cell lines. The peptides derive from hot spots within antigens and enlarge the antigen coverage. Spliced peptides also represent a large number of antigens that would otherwise be neglected by patrolling T cells. These antigens tend to be long, hydrophobic, and basic. Thus, spliced peptides can be a key to identifying targets in an enlarged pool of antigens associated with cancer.
Keywords:	Base Sequence, Breast Neoplasms, Colonic Neoplasms, MHC Class I Genes, Neoplasm Antigens, Peptides, Protein Splicing, Tumor Cell Line
Source:	Cancer Immunology Research
ISSN:	2326-6066
Publisher:	American Association for Cancer Research
Volume:	7
Number:	1
Page Range:	62-76
Date:	January 2019
Official Publication:	https://doi.org/10.1158/2326-6066.CIR-18-0424
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