Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Diagnosis and treatment of NMO spectrum disorder and MOG-encephalomyelitis

[img]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
754kB

Item Type:Review
Title:Diagnosis and treatment of NMO spectrum disorder and MOG-encephalomyelitis
Creators Name:Borisow, N. and Mori, M. and Kuwabara, S. and Scheel, M. and Paul, F.
Abstract:Neuromyelitis optica spectrum disorders (NMOSD) are autoantibody mediated chronic inflammatory diseases. Serum antibodies (Abs) against the aquaporin-4 water channel lead to recurrent attacks of optic neuritis, myelitis and/or brainstem syndromes. In some patients with symptoms of NMOSD, no AQP4-Abs but Abs against myelin-oligodendrocyte-glycoprotein (MOG) are detectable. These clinical syndromes are now frequently referred to as "MOG-encephalomyelitis" (MOG-EM). Here we give an overview on current recommendations concerning diagnosis of NMOSD and MOG-EM. These include antibody and further laboratory testing, MR imaging and optical coherence tomography. We discuss therapeutic options of acute attacks as well as longterm immunosuppressive treatment, including azathioprine, rituximab, and immunoglobulins.
Keywords:Neuromyelitis Optica, Aquaporin-4 Antibodies, MOG-Encephalomyelitis, Diagnostic Criteria, Immunosuppressive Treatment
Source:Frontiers in Neurology
ISSN:1664-2295
Publisher:Frontiers Research Foundation (Switzerland)
Volume:9
Page Range:888
Date:October 2018
Official Publication:https://doi.org/10.3389/fneur.2018.00888
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library