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A novel allele for inducible Cre expression in germinal center B cells

Item Type:Editorial
Title:A novel allele for inducible Cre expression in germinal center B cells
Creators Name:Weber, T. and Seagal, J. and Winkler, W. and Wirtz, T. and Chu, V.T. and Rajewsky, K.
Abstract:The germinal center reaction is essential for efficient humoral immunity, but it can also give rise to B cell lymphomas. Cre/loxP-mediated conditional gene knock-out or knock-in can be used for the genetic manipulation of germinal center B cells in vivo. Here we present a novel allele, Cγ1-CreERT2, that allows for timed activation of Cre recombinase in a small fraction of germinal center B cells. This allele will be useful to study normal and malignant germinal center B cell development in vivo.
Keywords:Germinal Center, B Cells, CreERT2, Conditional Knock-Out, Conditional Knock-In, Animals, Mice
Source:European Journal of Immunology
ISSN:0014-2980
Publisher:Wiley (U.S.A.)
Volume:49
Number:1
Page Range:192-194
Date:January 2019
Official Publication:https://doi.org/10.1002/eji.201847863
PubMed:View item in PubMed

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