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Predicting chronic copper and nickel reproductive toxicity to Daphnia pulex-pulicaria from whole-animal metabolic profiles

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Item Type:Article
Title:Predicting chronic copper and nickel reproductive toxicity to Daphnia pulex-pulicaria from whole-animal metabolic profiles
Creators Name:Taylor, N.S. and Kirwan, J.A. and Johnson, C. and Yan, N.D. and Viant, M.R. and Gunn, J.M. and McGeer, J.C.
Abstract:The emergence of omics approaches in environmental research has enhanced our understanding of the mechanisms underlying toxicity; however, extrapolation from molecular effects to whole-organism and population level outcomes remains a considerable challenge. Using environmentally relevant, sublethal, concentrations of two metals (Cu and Ni), both singly and in binary mixtures, we integrated data from traditional chronic, partial life-cycle toxicity testing and metabolomics to generate a statistical model that was predictive of reproductive impairment in a Daphnia pulex-pulicaria hybrid that was isolated from an historically metal-stressed lake. Furthermore, we determined that the metabolic profiles of organisms exposed in a separate acute assay were also predictive of impaired reproduction following metal exposure. Thus we were able to directly associate molecular profiles to a key population response - reproduction, a key step towards improving environmental risk assessment and management.
Keywords:Ecotoxicology, Environmental Risk Assessment, Metal Mixtures, PLS-R, Metabolomics, Mass Spectrometry, Animals, Daphnia
Source:Environmental Pollution
ISSN:0269-7491
Publisher:Elsevier (U.K.)
Volume:212
Page Range:325-329
Date:May 2016
Official Publication:https://doi.org/10.1016/j.envpol.2016.01.074
PubMed:View item in PubMed

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