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Specialized mechanoreceptor systems in rodent glabrous skin

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Item Type:Article
Title:Specialized mechanoreceptor systems in rodent glabrous skin
Creators Name:Walcher, J. and Ojeda-Alonso, J. and Haseleu, J. and Oosthuizen, M.K. and Rowe, A.H. and Bennett, N.C. and Lewin, G.R.
Abstract:Rodents use their forepaws to actively interact with their tactile environment. Studies on the physiology and anatomy of glabrous skin that makes up the majority of the forepaw are almost non-existent in the mouse. Here we developed a preparation to record from single sensory fibers of the forepaw and compared anatomical and physiological receptor properties to those of the hind paw glabrous and hairy skin. We found that the mouse forepaw skin is equipped with a very high density of mechanoreceptors; > 3 fold more than hind paw glabrous skin. In addition, rapidly adapting mechanoreceptors that innervate Meissner's corpuscles of the forepaw were several-fold more sensitive to slowly moving mechanical stimuli compared to their counterparts in the hind paw glabrous skin. All other mechanoreceptors types as well as myelinated nociceptors had physiological properties that were invariant regardless of which skin area they occupied. We discovered a novel D-hair receptor innervating a small group of hairs in the middle of the hind paw glabrous skin in mice. These glabrous skin D-hair receptors were direction sensitive albeit with an orientation sensitivity opposite to that described for hairy skin D-hair receptors. Glabrous skin hairs do not occur in all rodents, but are present in North American and African rodent species that diverged more than 65 million years ago. The function of these specialized hairs is unknown, but they are nevertheless evolutionarily very ancient. Our study reveals novel physiological specializations of mechanoreceptors in the glabrous skin that likely evolved to facilitate tactile exploration. This article is protected by copyright. All rights reserved.
Keywords:Evolution, Mechanoreceptor, Touch Sensation, Animals, Mice
Source:Journal of Physiology
ISSN:0022-3751
Publisher:Wiley (U.K.)
Volume:596
Number:20
Page Range:4995-5016
Date:15 October 2018
Official Publication:https://doi.org/10.1113/JP276608
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed
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https://edoc.mdc-berlin.de/17668/Preprint version

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