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VGLUT2 functions as a differential marker for hippocampal output neurons

Item Type:Preprint
Title:VGLUT2 functions as a differential marker for hippocampal output neurons
Creators Name:Wozny, C. and Beed, P. and Nitzan, N. and Poessnecker, Y. and Rost, B.R. and Schmitz, D.
Abstract:The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.
Keywords:Channelrhodopsin-2, Entorhinal Cortex, Hippocampus, Subiculum, Synaptic Transmission, VGLUT2
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory (U.S.A.)
Article Number:348227
Date:17 June 2018
Official Publication:https://doi.org/10.1101/348227
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https://edoc.mdc-berlin.de/17804/Final version

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