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A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors

Item Type:Article
Title:A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors
Creators Name:Aidhen, I.S. and Mukkamala, R. and Weidner, C. and Sauer, S.
Abstract:A common building block for the synthesis of amorfrutin and cajaninstilbene acid derivatives has been developed. The library of synthesized compounds has enabled identification of new nontoxic ligands of peroxisome proliferator-activated receptors (PPAR) and potential inhibitors of the transcriptional corepressor protein NCoR. The biological data holds promise in identification of new potential leads for the antidiabetic drug discovery process.
Keywords:Hypoglycemic Agents Hypoglycemic Agents, Ligands, Molecular Structure, Peroxisome Proliferator-Activated Receptors, Salicylates, Stilbenes
Source:Organic Letters
ISSN:1523-7052
Publisher:American Chemical Society (U.S.A)
Volume:17
Number:2
Page Range:194-197
Date:16 January 2015
Official Publication:https://doi.org/10.1021/ol503135u
PubMed:View item in PubMed

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