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Amorfrutins are natural PPARγ agonists with potent anti-inflammatory properties

Item Type:Article
Title:Amorfrutins are natural PPARγ agonists with potent anti-inflammatory properties
Creators Name:Fuhr, L. and Rousseau, M. and Plauth, A. and Schroeder, F.C. and Sauer, S.
Abstract:Amorfrutins are isoprenoid-substituted benzoic acid derivatives, which were found in Amorpha fruticosa L. (bastard indigo) and in Glycyrrhiza foetida Desf. (licorice). Recently, amorfrutins were shown to be selective activators of the nuclear receptor PPARγ. Here, we investigated the effects and PPARγ-based mechanisms of reducing inflammation in colon cells by treatment with amorfrutins. In TNF-α-stimulated colon cells amorfrutin A (1) reduced significantly the expression and secretion of several inflammation mediators, in part due to interaction with PPARγ. These results support the hypothesis that amorfrutins may have the potential to treat inflammation disorders such as chronic inflammatory bowel diseases.
Keywords:Anti-Inflammatory Agents, Cytoplasmic and Nuclear Receptors, Fabaceae, Glycyrrhiza, Molecular Structure, PPAR Gamma, Salicylates, Stilbenes, Tumor Necrosis Factor-alpha
Source:Journal of Natural Products
ISSN:1520-6025
Publisher:American Chemical Society (U.S.A.) / American Society of Pharmacognosy (U.S.A.)
Volume:78
Number:5
Page Range:1160-1164
Date:22 May 2015
Official Publication:https://doi.org/10.1021/np500747y
PubMed:View item in PubMed

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