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The association between brain volume, cortical brain infarcts, and physical frailty

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Item Type:Article
Title:The association between brain volume, cortical brain infarcts, and physical frailty
Creators Name:Kant, I.M.J. and de Bresser, J. and van Montfort, S.J.T. and Aarts, E. and Verlaan, J.J. and Zacharias, N. and Winterer, G. and Spies, C. and Slooter, A.J.C. and Hendrikse, J.
Abstract:Physical frailty is an age-associated syndrome of decreased reserve leading to vulnerability to physiological stressors and associated with negative outcomes. The underlying structural brain abnormalities of physical frailty are unclear. We investigated the association between brain volume, cortical brain infarcts, and physical frailty. In this multicenter study, 214 nondemented participants were classified as frail (n = 32), prefrail (n = 107), or nonfrail (n = 75) based on the Fried frailty phenotype. The associations between frailty and brain volumes and cortical brain infarcts were investigated by linear or logistic regression analyses. Participants in the frail group showed a lower total brain volume (-19.67 mL [95% confidence interval -37.84 to -1.50]) and lower gray matter volume (-12.19 mL [95% confidence interval -23.84 to -0.54]) compared to nonfrail participants. Frailty was associated with cortical brain infarcts [frail 16% [n = 5], prefrail 11% [n = 12], and nonfrail 3% [n = 2]). Reduced total brain volume and gray matter volume and increased cortical brain infarcts seem therefore to be part of the structural substrate of the physical frailty phenotype.
Keywords:Physical Frailty, Aging, Neurodegenerative Brain Changes, Neurovascular Brain Changes, Magnetic Resonance Imaging
Source:Neurobiology of Aging
ISSN:0197-4580
Publisher:Elsevier (U.S.A.)
Volume:70
Page Range:247-253
Date:October 2018
Official Publication:https://doi.org/10.1016/j.neurobiolaging.2018.06.032
PubMed:View item in PubMed

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