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Ligands for the nuclear peroxisome proliferator-activated receptor gamma

Item Type:Review
Title:Ligands for the nuclear peroxisome proliferator-activated receptor gamma
Creators Name:Sauer, S.
Abstract:Nuclear receptors are ligand-activated transcription factors, which represent a primary class of drug targets. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is a key player in various biological processes. PPARγ is widely known as the target protein of the thiazolidinediones for treating type 2 diabetes. Moreover, PPARγ ligands can induce anti-inflammatory and potentially additional beneficial effects. Recent mechanistic insights of PPARγ modulation give hope the next generation of efficient PPARγ-based drugs with fewer side effects can be developed. Furthermore, chemical approaches that make use of synergistic action of combinatorial ligands are promising alternatives for providing tailored medicine. Lessons learned from fine-tuning the action of PPARγ can provide avenues for efficient molecular intervention via many other nuclear receptors to combat common diseases.
Keywords:Hypoglycemic Agents, Ligands, PPAR gamma, Protein Binding, Thiazolidinediones, Animals
Source:Trends in Pharmacological Sciences
ISSN:0165-6147
Publisher:Elsevier (U.K.)
Volume:36
Number:10
Page Range:688-704
Date:October 2015
Additional Information:Erratum in: Trends Pharmacol Sci 37(2):167.
Official Publication:https://doi.org/10.1016/j.tips.2015.06.010
PubMed:View item in PubMed

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