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| Item Type: | Article |
|---|---|
| Title: | Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice |
| Creators Name: | Hoser, D., Schön, C., Loddenkemper, C., Lohneis, P., Kühl, A.A., Sommermann, T., Blankenstein, T. and Willimsky, G. |
| Abstract: | To date, little is known about the interaction between (pre-)malignant B cells and T cells. We generated transgenic mice that allow B cell-specific induction of the oncogene SV40 large T-antigen (TAg) to analyze the role of oncogene-specific T cells during sporadic B cell lymphoma development. Constitutive TAg expression in CD19-Cre x LoxP Tag mice resulted in TAg-tolerant CD8(+) T cells and development of B cell lymphomas. In contrast, CD19 CreER(T2) x LoxP Tag mice retained TAg-competent CD8(+) T cells at time of oncogene induction and TAg expression in few B cells of adult mice resulted in exceptionally rare lymphoma formation late in life. Increased lymphoma incidence in the absence of TAg-specific T cells suggested T cell-mediated inhibition of lymphoma progression. However, TAg-initiated B cells were not eliminated by T cells and detected long-term. Our results demonstrate a failure of the immune system to eradicate lymphoma-initiating B cells, retaining the risk of lymphoma development. |
| Keywords: | B-Cell Lymphoma, B-Lymphocytes, CD8-Positive T-Lymphocytes, Cellular Immunity, Knockout Mice, Polyomavirus Transforming Antigens, Animals, Mice |
| Source: | Blood |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Volume: | 132 |
| Number: | 9 |
| Page Range: | 924-934 |
| Date: | 30 August 2018 |
| Official Publication: | https://doi.org/10.1182/blood-2018-02-834036 |
| PubMed: | View item in PubMed |
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