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VZV-associated acute retinal necrosis in a patient with MS treated with natalizumab

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Item Type:Editorial
Title:VZV-associated acute retinal necrosis in a patient with MS treated with natalizumab
Creators Name:Pawlitzki, M. and Teuber, J. and Campe, C. and Wagner, M. and Schuart, C. and Paul, F. and Bittner, D.
Abstract:Natalizumab (NTZ) was the first approved humanized monoclonal antibody in highly active relapsing remitting MS (RRMS). Because of the mechanism of inhibiting the migration of immune cells through the blood-brain barrier into the CNS, NTZ is associated with an increased risk of progressive multifocal leukoencephalopathy (PML) by the John Cunningham virus (JCV). Infections with other neurotropic viruses are rarely reported. We present a case of rapid retinal necrosis induced by varicella zoster virus (VZV) in a patient with RRMS under long-term NTZ treatment.
Source:Neurology Neuroimmunology & Neuroinflammation
ISSN:2332-7812
Publisher:American Academy of Neurology (U.S.A.)
Volume:5
Number:5
Page Range:e475
Date:1 September 2018
Official Publication:https://doi.org/10.1212/NXI.0000000000000475
PubMed:View item in PubMed

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