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A general one-pot synthesis of 2H-indazoles using an organophosphorus-silane system

Item Type:Article
Title:A general one-pot synthesis of 2H-indazoles using an organophosphorus-silane system
Creators Name:Schoene, J. and Bel Abed, H. and Schmieder, P. and Christmann, M. and Nazaré, M.
Abstract:A simple and direct approach for the regioselective construction of the privileged 2H‐indazole scaffold is described. The developed one‐pot strategy involves phospholene‐mediated N−N bond formation to access 2H‐indazoles. The amount of organophosphorus reagent was minimized by recycling the phospholene oxide with organosilane reductants. Starting from functionalized 2‐nitrobenzaldehydes and primary amines, a mild reductive cyclization, involving the use of commercially available phospholene oxide and silanes, delivered a wide variety of substituted 2H‐indazoles in good to excellent yields.
Source:Chemistry - A European Journal
ISSN:0947-6539
Publisher:Wiley-Blackwell (Germany)
Volume:24
Number:36
Page Range:9090-9100
Date:26 June 2018
Official Publication:https://doi.org/10.1002/chem.201800763
PubMed:View item in PubMed

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