Enhanced activity of CMP-neuAc:Gal beta 1-4GlcNAc:alpha 2,6- sialyltransferase in metastasizing human colorectal tumor tissue and serum of tumor patients

Item Type:	Article
Title:	Enhanced activity of CMP-neuAc:Gal beta 1-4GlcNAc:alpha 2,6- sialyltransferase in metastasizing human colorectal tumor tissue and serum of tumor patients
Creators Name:	Gessner, P. and Riedl, S. and Quentmaier, A. and Kemmner, W.
Abstract:	The activity of sialyltransferases with different linkage specificities, of a Gal beta 1-4GlcNAc:alpha 2,6-sialyltransferase and a Gal beta 1-4GlcNAc:alpha 2,3-sialyltransferase, was studied in human colorectal tumor tissue from surgical specimens, normal mucosa, liver and liver metastases, and serum of patients suffering from colorectal carcinomas. While alpha 2,3-specific activity was equally high in tumor and mucosa samples, the activity of the alpha 2,6-specific enzyme was increased in tumor tissue and particularly in metastasizing tumors. Also, compared to healthy individuals, serum of patients suffering from metastasizing tumors contained a significantly higher activity of the alpha 2,6-specific enzyme. These results demonstrate that specific sialyltransferase isoforms are expressed in metastasizing tumors and that determination of such isoforms may be a new means for tumor detection and monitoring.
Keywords:	Alpha2,6-Sialyltransferase, Human Colorectal Tumor Metastasis, Serum Determinations, Tumor Monitoring
Source:	Cancer Letters
ISSN:	0304-3835
Volume:	75
Number:	3
Page Range:	143-149
Date:	20 December 1993
Official Publication:	https://doi.org/10.1016/0304-3835(93)90056-F
PubMed:	View item in PubMed

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