Item Type: | Article |
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Title: | Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth |
Creators Name: | Pan, Y. and Xiong, M. and Chen, R. and Ma, Y. and Corman, C. and Maricos, M. and Kindler, U. and Semtner, M. and Chen, Y.H. and Dahiya, S. and Gutmann, D.H. |
Abstract: | Pediatric low-grade gliomas (LGGs) frequently do not engraft in immunocompromised mice, limiting their use as an experimental platform. In contrast, murine Neurofibromatosis-1 (Nf1) optic LGG stem cells (o-GSCs) form glioma-like lesions in wild-type, but not athymic, mice following transplantation. Here, we show that the inability of athymic mice to support o-GSC engraftment results from impaired microglia/macrophage function, including reduced expression of Ccr2 and Ccl5, both of which are required for o-GSC engraftment and Nf1 optic glioma growth. Impaired Ccr2 and Ccl5 expression in athymic microglia/macrophages was restored by T-cell exposure, establishing T-cell-microglia/macrophage interactions as critical stromal determinants that support NF1 LGG growth. |
Keywords: | Tumor Microenvironment, Stroma, Monocyte, Chemokines, Animals, Mice |
Source: | Genes & Development |
ISSN: | 0890-9369 |
Publisher: | Cold Spring Harbor Laboratory Press |
Volume: | 32 |
Number: | 7-8 |
Page Range: | 491-496 |
Date: | 9 April 2018 |
Official Publication: | https://doi.org/10.1101/gad.310797.117 |
External Fulltext: | View full text on PubMed Central |
PubMed: | View item in PubMed |
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