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Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth

Item Type:Article
Title:Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth
Creators Name:Pan, Y. and Xiong, M. and Chen, R. and Ma, Y. and Corman, C. and Maricos, M. and Kindler, U. and Semtner, M. and Chen, Y.H. and Dahiya, S. and Gutmann, D.H.
Abstract:Pediatric low-grade gliomas (LGGs) frequently do not engraft in immunocompromised mice, limiting their use as an experimental platform. In contrast, murine Neurofibromatosis-1 (Nf1) optic LGG stem cells (o-GSCs) form glioma-like lesions in wild-type, but not athymic, mice following transplantation. Here, we show that the inability of athymic mice to support o-GSC engraftment results from impaired microglia/macrophage function, including reduced expression of Ccr2 and Ccl5, both of which are required for o-GSC engraftment and Nf1 optic glioma growth. Impaired Ccr2 and Ccl5 expression in athymic microglia/macrophages was restored by T-cell exposure, establishing T-cell-microglia/macrophage interactions as critical stromal determinants that support NF1 LGG growth.
Keywords:Tumor Microenvironment, Stroma, Monocyte, Chemokines, Animals, Mice
Source:Genes & Development
ISSN:0890-9369
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Volume:32
Number:7-8
Page Range:491-496
Date:9 April 2018
Official Publication:https://doi.org/10.1101/gad.310797.117
PubMed:View item in PubMed

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