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| Item Type: | Review |
|---|---|
| Title: | The CRISPR/Cas9 system sheds new lights on the biology of protozoan parasites |
| Creators Name: | Grzybek, M. and Golonko, A. and Górska, A. and Szczepaniak, K. and Strachecka, A. and Lass, A. and Lisowski, P. |
| Abstract: | The CRISPR/Cas9 system, a natural defence system of bacterial organisms, has recently been used to modify genomes of the most important protozoa parasites. Successful genome manipulations with the CRISPR/Cas9 system are changing the present view of genetics in parasitology. The application of this system offers a major chance to overcome the current restriction in culturing, maintaining and analysing protozoan parasites, and allows dynamic analysis of parasite genes functions, leading to a better understanding of pathogenesis. CRISPR/Cas9 system will have a significant influence on the process of developing novel drugs and treatment strategies against protozoa parasites. |
| Keywords: | CRISPR, Cas9, Genetic Modification, Protozoa, Apicomplexa, Genome Editing, Animals |
| Source: | Applied Microbiology and Biotechnology |
| ISSN: | 0175-7598 |
| Publisher: | Springer |
| Volume: | 102 |
| Number: | 11 |
| Page Range: | 4629-4640 |
| Date: | June 2018 |
| Official Publication: | https://doi.org/10.1007/s00253-018-8927-3 |
| PubMed: | View item in PubMed |
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