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The CRISPR/Cas9 system sheds new lights on the biology of protozoan parasites

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Item Type:Review
Title:The CRISPR/Cas9 system sheds new lights on the biology of protozoan parasites
Creators Name:Grzybek, M. and Golonko, A. and Górska, A. and Szczepaniak, K. and Strachecka, A. and Lass, A. and Lisowski, P.
Abstract:The CRISPR/Cas9 system, a natural defence system of bacterial organisms, has recently been used to modify genomes of the most important protozoa parasites. Successful genome manipulations with the CRISPR/Cas9 system are changing the present view of genetics in parasitology. The application of this system offers a major chance to overcome the current restriction in culturing, maintaining and analysing protozoan parasites, and allows dynamic analysis of parasite genes functions, leading to a better understanding of pathogenesis. CRISPR/Cas9 system will have a significant influence on the process of developing novel drugs and treatment strategies against protozoa parasites.
Keywords:CRISPR, Cas9, Genetic Modification, Protozoa, Apicomplexa, Genome Editing, Animals
Source:Applied Microbiology and Biotechnology
ISSN:0175-7598
Publisher:Springer (Germany)
Volume:102
Number:11
Page Range:4629-4640
Date:June 2018
Official Publication:https://doi.org/10.1007/s00253-018-8927-3
PubMed:View item in PubMed

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