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Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model

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Item Type:Article
Title:Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model
Creators Name:Weiser, C. and Petkova, M.V. and Rengstl, B. and Döring, C. and von Laer, D. and Hartmann, S. and Küppers, R. and Hansmann, M.L. and Newrzela, S.
Abstract:The mechanisms involved in malignant transformation of mature B and T lymphocytes are still poorly understood. In a previous study, we compared gene expression profiles of the tumor cells of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) to their normal cellular counterparts and found the basic leucine zipper protein ATF-like 3 (BATF3) to be significantly upregulated in the tumor cells of both entities. To assess the oncogenic potential of BATF3 in lymphomagenesis and to dissect the molecular interactions of BATF3 in lymphoma cells, we retrovirally transduced murine mature T and B cells with a BATF3-encoding viral vector and transplanted each population into Rag1-deficient recipients. Intriguingly, BATF3-expressing B lymphocytes readily induced B-cell lymphomas after characteristic latencies, whereas T-cell transplanted animals remained healthy throughout the observation time. Further analyses revealed a germinal center B-cell-like phenotype of most BATF3-initiated lymphomas. In a multiple myeloma cell line, BATF3 inhibited BLIMP1 expression, potentially illuminating an oncogenic action of BATF3 in B-cell lymphomagenesis. In conclusion, BATF3 overexpression induces malignant transformation of mature B cells and might serve as a potential target in B-cell lymphoma treatment.
Keywords:BATF3, B-Cell Immunology, B-Cell Lymphoma, Germinal Center, Oncogene, Animals, Mice
Source:Oncotarget
ISSN:1949-2553
Publisher:Impact Journals (U.S.A.)
Volume:9
Number:22
Page Range:15942-15951
Date:23 March 2018
Official Publication:https://doi.org/10.18632/oncotarget.24639
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed

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