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Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall

Item Type:Article
Title:Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
Creators Name:Lindblom, P. and Gerhardt, H. and Liebner, S. and Abramsson, A. and Enge, M. and Hellstrom, M. and Backstrom, G. and Fredriksson, S. and Landegren, U. and Nystrom, H.C. and Bergstrom, G. and Dejana, E. and Ostman, A. and Lindahl, P. and Betsholtz, C.
Abstract:Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the pericellular space. To address the role of PDGF-B retention in vivo, we deleted the retention motif by gene targeting in mice. This resulted in defective investment of pericytes in the microvessel wall and delayed formation of the renal glomerulus mesangium. Long-term effects of lack of PDGF-B retention included severe retinal deterioration, glomerulosclerosis, and proteinuria. We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice.
Keywords:PDGF, Cell Retention, Heparan Sulphate Proteoglycan, Pericyte, Mesangial Cell, Retina, Animals, Mice
Source:Genes & Development
ISSN:0890-9369
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Volume:17
Number:15
Page Range:1835-1840
Date:1 August 2003
Official Publication:https://doi.org/10.1101/gad.266803
PubMed:View item in PubMed

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