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Role of pericytes in vascular morphogenesis

Item Type:Article
Title:Role of pericytes in vascular morphogenesis
Creators Name:Betsholtz, C. and Lindblom, P. and Gerhardt, H.
Abstract:Pericytes are solitary, smooth muscle-like mural cells that invest the wall of microvessels. For a long time, the functional significance of the presence and distribution of pericytes in the microvasculature was unclear. However, in recent years, the application of experimental genetics to the PDGF-B/PDGFRbeta signaling pathway in mice has provided a range of mutants with primary defects in pericytes, allowing for studies of the physiological consequences of pericyte deficiency in developmental angiogenesis and adult physiology. Interestingly, some of the phenotypic consequences of these mutations resemble human diseases, such as diabetic retinopathy. The studies have also led to the discovery of critical mechanisms involved in pericyte recruitment and differentiation. The present review focuses on genetic data suggesting that pericytes take active part in developmental angiogenic processes.
Keywords:Morphogenesis, Pericytes, Physiologic Neovascularization, Platelet-Derived Growth Factor, Retinal Vessels, Vascular Endothelium, Animals
Source:Experientia Supplementum
Series Name:Experientia Supplementum
Title of Book:Mechanisms of Angiogenesis
Page Range:115-125
Official Publication:https://doi.org/10.1007/3-7643-7311-3_8
PubMed:View item in PubMed

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