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Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment

Item Type:Article
Title:Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment
Creators Name:Kurup, S. and Abramsson, A. and Li, J.P. and Lindahl, U. and Kjellen, L. and Betsholtz, C. and Gerhardt, H. and Spillmann, D.
Abstract:HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. It has been proposed that HS controls the diffusion, and thus the availability, of platelet-derived growth factor B that is needed for pericyte recruitment around newly formed capillaries. The present paper summarizes our studies on the importance of HS structure in this regulatory process.
Keywords:Extracellular Matrix, Growth Factor, Heparan Sulphate, Pericyte Recruitment, Platelet-Drived Growth Factor (PDGF), Retention Motif, Animals
Source:Biochemical Society Transactions
ISSN:0300-5127
Publisher:Biochemical Society (U.K.)
Volume:34
Number:3
Page Range:454-455
Date:1 June 2006
Official Publication:https://doi.org/10.1042/BST0340454
PubMed:View item in PubMed

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