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Angiogenesis: a team effort coordinated by notch

Item Type:Review
Title:Angiogenesis: a team effort coordinated by notch
Creators Name:Phng, L.K. and Gerhardt, H.
Abstract:The past two decades of angiogenesis research have identified a wealth of pro- and antiangiogenic signals originating from the tissue environment, which control blood vessel density and function. Understanding when and how blood vessels respond to the combination of signals they encounter to achieve a balanced cellular response is a major challenge for the field of developmental and tumor angiogenesis. This review focuses on how endothelial cell-cell communication via the Notch pathway contributes to this signal integration and is essential for functional vessel patterning.
Keywords:Angiogenesis Inhibitors, Biological Models, Blood Vessels, Cell Adhesion, Cell Movement, Endothelial Cells, Notch Receptors, Pathologic Neovascularization, Phenotype, Signal Transduction, Animals
Source:Developmental Cell
Publisher:Cell Press
Page Range:196-208
Date:17 February 2009
Official Publication:https://doi.org/10.1016/j.devcel.2009.01.015
PubMed:View item in PubMed

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