VEGF and endothelial guidance in angiogenic sprouting

Item Type:	Review
Title:	VEGF and endothelial guidance in angiogenic sprouting
Creators Name:	Gerhardt, H.
Abstract:	The cellular actions of VEGF need to be coordinated to guide vascular patterning during sprouting angiogenesis. Individual endothelial tip cells lead and guide the blood vessel sprout, while neighbouring stalk cells proliferate and form the vascular lumen. Recent studies illustrate how endothelial DLL4/NOTCH signalling, stimulated by VEGF, regulates the sprouting response by limiting tip cell formation in the stalk. The spatial distribution of VEGF, in turn, regulates the shape of the ensuing sprout by directing tip cell migration and determining stalk cell proliferation.
Keywords:	VEGF, Notch, Angiogenesis, Tip Cells, Vascular Patterning
Source:	Organogenesis
ISSN:	1547-6278
Publisher:	Landes Bioscience
Volume:	4
Number:	4
Page Range:	241-246
Date:	October 2008
Official Publication:	https://doi.org/10.4161/org.4.4.7414
PubMed:	View item in PubMed

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