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Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish

Item Type:Article
Title:Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish
Creators Name:Geudens, I. and Herpers, R. and Hermans, K. and Segura, I. and Ruiz de Almodovar, C. and Bussmann, J. and De Smet, F. and Vandevelde, W. and Hogan, B.M. and Siekmann, A. and Claes, F. and Moore, J.C. and Pistocchi, A.S. and Loges, S. and Mazzone, M. and Mariggi, G. and Bruyère, F. and Cotelli, F. and Kerjaschki, D. and Noël, A. and Foidart, J.M. and Gerhardt, H. and Ny, A. and Langenberg, T. and Lawson, N.D. and Duckers, H.J. and Schulte-Merker, S. and Carmeliet, P. and Dewerchin, M.
Abstract:Objective: To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development. Methods and results: In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates. Conclusion: These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network.
Keywords:Vascular Biology, Gene Silencing, Lymphangiogenesis, Notch Signaling, Animals, Zebrafish
Source:Arteriosclerosis Thrombosis and Vascular Biology
ISSN:1079-5642
Publisher:American Heart Association (U.S.A.)
Volume:30
Number:9
Page Range:1695-1702
Date:September 2010
Official Publication:https://doi.org/10.1161/ATVBAHA.110.203034
PubMed:View item in PubMed

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