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Basic and therapeutic aspects of angiogenesis

Item Type:Review
Title:Basic and therapeutic aspects of angiogenesis
Creators Name:Potente, M. and Gerhardt, H. and Carmeliet, P.
Abstract:Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and they contribute to disease progression. Therapeutic approaches to block vascular supply have reached the clinic, but limited efficacy and resistance pose unresolved challenges. Recent insights establish how endothelial cells communicate with each other and with their environment to form a branched vascular network. The emerging principles of vascular growth provide exciting new perspectives, the translation of which might overcome the current limitations of pro- and antiangiogenic medicine.
Keywords:Angiogenesis Inhibitors, Blood Vessels, Endothelial Cells, Inflammation, Pathologic Neovascularization, Physiologic Neovascularization, Animals
Source:Cell
ISSN:0092-8674
Publisher:Cell Press (U.S.A.)
Volume:146
Number:6
Page Range:873-887
Date:16 September 2011
Official Publication:https://doi.org/10.1016/j.cell.2011.08.039
PubMed:View item in PubMed

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