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N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy

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Item Type:Article
Title:N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy
Creators Name:Håkansson, J. and Ståhlberg, A. and Wolfhagen Sand, F. and Gerhardt, H. and Semb, H.
Abstract:Background: Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia. The underlying mechanism for epiretinal neovascularization (tuft formation), which contributes to blindness, has yet to be identified. Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis. Methodology/Principal Findings: Notably, during oxygen induced retinopathy (OIR) N-CAM accumulated on astrocytes surrounding the epiretinal tufts. Here, we show that N-CAM ablation results in reduced vascular tuft formation due to reduced endothelial cell proliferation despite an elevation in VEGFA mRNA expression, whereas retinal developmental angiogenesis was unaffected. Conclusion/Significance: We conclude that N-CAM exhibits a regulatory function in pathological angiogenesis in OIR. This is a novel finding that can be of clinical relevance in diseases associated with proliferative vasculopathy.
Keywords:Cell Proliferation, Diabetic Retinopathy, Endothelial Cells, Hypoxia, Neural Cell Adhesion Molecules, Pathologic Neovascularization, Retinal Neovascularization, Retinal Vessels, Vascular Endothelial Growth Factor A, Animals, Mice
Source:PLoS ONE
ISSN:1932-6203
Publisher:Public Library of Science (U.S.A.)
Volume:6
Number:10
Page Range:e26026
Date:17 October 2011
Official Publication:https://doi.org/10.1371/journal.pone.0026026
PubMed:View item in PubMed

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