N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy

Håkansson, J.; Ståhlberg, A.; Wolfhagen Sand, F.; Gerhardt, H.; Semb, H.

N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy

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Item Type:	Article
Title:	N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy
Creators Name:	Håkansson, J., Ståhlberg, A., Wolfhagen Sand, F., Gerhardt, H. and Semb, H.
Abstract:	Background: Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia. The underlying mechanism for epiretinal neovascularization (tuft formation), which contributes to blindness, has yet to be identified. Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis. Methodology/Principal Findings: Notably, during oxygen induced retinopathy (OIR) N-CAM accumulated on astrocytes surrounding the epiretinal tufts. Here, we show that N-CAM ablation results in reduced vascular tuft formation due to reduced endothelial cell proliferation despite an elevation in VEGFA mRNA expression, whereas retinal developmental angiogenesis was unaffected. Conclusion/Significance: We conclude that N-CAM exhibits a regulatory function in pathological angiogenesis in OIR. This is a novel finding that can be of clinical relevance in diseases associated with proliferative vasculopathy.
Keywords:	Cell Proliferation, Diabetic Retinopathy, Endothelial Cells, Hypoxia, Neural Cell Adhesion Molecules, Pathologic Neovascularization, Retinal Neovascularization, Retinal Vessels, Vascular Endothelial Growth Factor A, Animals, Mice
Source:	PLoS ONE
ISSN:	1932-6203
Publisher:	Public Library of Science
Volume:	6
Number:	10
Page Range:	e26026
Date:	17 October 2011
Official Publication:	https://doi.org/10.1371/journal.pone.0026026
PubMed:	View item in PubMed

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