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Tissue guidance without filopodia

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Item Type:Review
Title:Tissue guidance without filopodia
Creators Name:Wacker, A. and Gerhardt, H. and Phng, L.K.
Abstract:Filopodia are highly dynamic, rod-like protrusions that are found in abundance at the leading edge of migrating cells such as endothelial tip cells and at axonal growth cones of developing neurons. One proposed function of filopodia is that of an environmental probe, which serves to sense guidance cues during neuronal pathfinding and blood vessel patterning. However, recent studies show that tissue guidance occurs unhindered in the absence of filopodia, suggesting a dispensability of filopodia in this process. Here, we discuss evidence that support as well as dispute the role of filopodia in guiding the formation of stereotypic neuronal and blood vessel patterns.
Keywords:Cell Guidance, Cell Migration, Endothelial Tip Cell, Filopodia, Neuronal Pathfinding, Vascular Patterning
Source:Communicative & Integrative Biology
ISSN:1942-0889
Volume:7
Number:1
Page Range:e28820
Date:9 April 2014
Official Publication:https://doi.org/10.4161/cib.28820
PubMed:View item in PubMed

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