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Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy

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Item Type:Review
Title:Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy
Creators Name:Oertel, F.C. and Zimmermann, H. and Paul, F. and Brandt, A.U.
Abstract:Neuromyelitis optica spectrum disorders (NMOSD) are mostly relapsing inflammatory disorders of the central nervous system (CNS). Optic neuritis (ON) is the first NMOSD-related clinical event in 55% of the patients, which causes damage to the optic nerve and leads to visual impairment. Retinal optical coherence tomography (OCT) has emerged as a promising method for diagnosis of NMOSD and potential individual monitoring of disease course and severity. OCT not only detects damage to the afferent visual system caused by ON but potentially also NMOSD-specific intraretinal pathology, i.e. astrocytopathy. This article summarizes retinal involvement in NMOSD and reviews OCT methods that could be used now and in the future, for differential diagnosis, for monitoring of disease course, and in clinical trials.
Keywords:Neuromyelitis Optica, Optical Coherence Tomography, Differential Diagnosis, Optic Neuritis, Retina, Disease Progression, Vision Disorders
Source:EPMA Journal
ISSN:1878-5085
Publisher:BioMed Central (U.K.)
Volume:9
Number:1
Page Range:21-33
Date:March 2018
Official Publication:https://doi.org/10.1007/s13167-017-0123-5
PubMed:View item in PubMed

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