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Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae

Item Type:Article
Title:Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae
Creators Name:Deubzer, H.E. and Obaro, S.K. and Newman, V.O. and Adegbola, R.A. and Greenwood, B.M. and Henderson, D.C.
Abstract:Prevention of nasopharyngeal colonization may reduce the burden of pneumococcal infection during infancy. Colostrum obtained from Gambian mothers who had been vaccinated with either Pneumovax II or Mengivax A&C (n=8 per group) during pregnancy was examined for inhibition of adherence of Streptococcus pneumoniae serotypes 6B and 14 to pharyngeal epithelial cells in vitro. Pneumococcal adherence was significantly reduced in the presence of breast milk (P< or =.0001 for S. pneumoniae serotype 14; P=.036 for serotype 6B), independent of the concentration of secretory IgA antibodies. Maternal vaccination with polyvalent pneumococcal polysaccharide vaccine boosts the capacity of colostrum to inhibit adherence of pneumococci to pharyngeal epithelial cells. In breast-feeding populations, maternal vaccination might prevent pneumococcal disease in young infants.
Keywords:Antibody Affinity, Bacterial Adhesion, Bacterial Antibodies, Colostrum, Cultured Cells, Double-Blind Method, Maternally-Acquired Immunity, Pharynx, Pneumococcal Infections, Epithelial Cells, Gambia, Immunoglobulin A, Pneumococcal Vaccines, Pregnancy, Streptococcus Pneumoniae
Source:Journal of Infectious Diseases
ISSN:0022-1899
Publisher:Oxford University Press (U.K.)
Volume:190
Number:10
Page Range:1758-1761
Date:15 November 2004
Official Publication:https://doi.org/10.1086/424597
PubMed:View item in PubMed

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