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Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells

Item Type:Article
Title:Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells
Creators Name:Schulte, J.H. and Kirfel, J. and Lim, S. and Schramm, A. and Friedrichs, N. and Deubzer, H.E. and Witt, O. and Eggert, A. and Buettner, R.
Abstract:Neuroblastoma, the most common extracranial solid tumour of childhood, is derived from neural crest progenitor cells. The TFAP2a transcription factor regulates neural crest patterning. We analysed TFAP2a protein expression in 97 primary neuroblastic tumors and report that TFAP2a was strongly expressed in poorly differentiated neuroblastomas. TFAP2a expression in tumor cells of differentiated neuroblastic tumors was below detection. TFAP2a was strongly expressed in 4 of 6 neuroblastoma cell lines tested, and TFAP2a siRNA mediated knock down in SH-EP cells reduced proliferation and induced a more differentiated phenotype associated with an increase in the expression of the differentiation marker neurotensin.
Keywords:Neuroblastoma, AP2alpha, TFAP2A, Differentiation, Ganglioneuroma, IHC, Neural Crest
Source:Cancer Letters
ISSN:0304-3835
Publisher:Elsevier (The Netherlands)
Volume:271
Number:1
Page Range:56-63
Date:18 November 2008
Official Publication:https://doi.org/10.1016/j.canlet.2008.05.039
PubMed:View item in PubMed

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