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Nestin expression identifies ependymoma patients with poor outcome

Item Type:Article
Title:Nestin expression identifies ependymoma patients with poor outcome
Creators Name:Milde, T. and Hielscher, T. and Witt, H. and Kool, M. and Mack, S.C. and Deubzer, H.E. and Oehme, I. and Lodrini, M. and Benner, A. and Taylor, M.D. and von Deimling, A. and Kulozik, A.E. and Pfister, S.M. and Witt, O. and Korshunov, A.
Abstract:Ependymomas are primary brain tumors found throughout the central nervous system (CNS) in children and adults. Currently, many treatment protocols stratify grade I and II ependymomas as low-risk tumors, whereas grade III anaplastic ependymomas are considered high-risk tumors. The prognostic significance of World Health Organization (WHO) grade II or III, however, remains debated, and it is furthermore increasingly recognized that the pathologic differentiation between grades II and III is arbitrary in daily practice, thus resulting in imprecise risk stratification. Therefore, prognostic markers enabling more precise stratification to guide treatment decisions are urgently needed. An analysis of n = 379 tumor samples revealed that protein expression of nestin, a marker for neural stem and progenitor cells established as a routine staining in most neuropathology centers, is associated with poor outcome in intracranial ependymomas. Most importantly, nestin-positive grade II ependymomas have the same prognosis as grade III ependymomas. Multivariable analysis demonstrates that nestin positivity is an independent marker for poor progression-free survival (PFS) and overall survival (OS). Gene expression analysis for transcriptionally co-regulated genes revealed a strong association of developmental and epigenetic processes with nestin. In summary, our data implicate nestin as a useful novel marker for intracranial ependymoma risk stratification easily implementable in routine diagnostics.
Keywords:Ependymoma, Nestin, Risk Stratification, WHO Grade
Source:Brain Pathology
ISSN:1015-6305
Publisher:International Society of Neuropathology (Switzerland)
Volume:22
Number:6
Page Range:848-860
Date:November 2012
Official Publication:https://doi.org/10.1111/j.1750-3639.2012.00600.x
PubMed:View item in PubMed

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