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Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project

Item Type:Article
Title:Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project
Creators Name:Winterer, G. and Androsova, G. and Bender, O. and Boraschi, D. and Borchers, F. and Dschietzig, T.B. and Feinkohl, I. and Fletcher, P. and Gallinat, J. and Hadzidiakos, D. and Haynes, J.D. and Heppner, F. and Hetzer, S. and Hendrikse, J. and Ittermann, B. and Kant, I.M.J. and Kraft, A. and Krannich, A. and Krause, R. and Kühn, S. and Lachmann, G. and van Montfort, S.J.T. and Müller, A. and Nürnberg, P. and Ofosu, K. and Pietsch, M. and Pischon, T. and Preller, J. and Renzulli, E. and Scheurer, K. and Schneider, R. and Slooter, A.J.C. and Spies, C. and Stamatakis, E. and Volk, H.D. and Weber, S. and Wolf, A. and Yürek, F. and Zacharias, N.
Abstract:Postoperative cognitive impairment is among the most common medical complications associated with surgical interventions - particularly in elderly patients. In our aging society, it is an urgent medical need to determine preoperative individual risk prediction to allow more accurate cost-benefit decisions prior to elective surgeries. So far, risk prediction is mainly based on clinical parameters. However, these parameters only give a rough estimate of the individual risk. At present, there are no molecular or neuroimaging biomarkers available to improve risk prediction and little is known about the etiology and pathophysiology of this clinical condition. In this short review, we summarize the current state of knowledge and briefly present the recently started BioCog project (Biomarker Development for Postoperative Cognitive Impairment in the Elderly), which is funded by the European Union. It is the goal of this research and development (R&D) project, which involves academic and industry partners throughout Europe, to deliver a multivariate algorithm based on clinical assessments as well as molecular and neuroimaging biomarkers to overcome the currently unsatisfying situation.
Keywords:Postoperative Delirium, Postoperative Cognitive Dysfunction, Neuroimaging, Molecular Biomarkers, Multivariate Prediction Algorithm
Source:European Psychiatry
Page Range:34-39
Date:April 2018
Official Publication:https://doi.org/10.1016/j.eurpsy.2017.10.004
PubMed:View item in PubMed

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