Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Millimeter spatial resolution in vivo sodium MRI of the human eye at 7 T using a dedicated radiofrequency transceiver array

[img]
Preview
PDF (Accepted Manuscript (final draft)) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB
[img] MS Word (Supporting Information)
2MB

Item Type:Article
Title:Millimeter spatial resolution in vivo sodium MRI of the human eye at 7 T using a dedicated radiofrequency transceiver array
Creators Name:Wenz, D. and Kuehne, A. and Huelnhagen, T. and Nagel, A.M. and Waiczies, H. and Weinberger, O. and Oezerdem, C. and Stachs, O. and Langner, S. and Seeliger, E. and Flemming, B. and Hodge, R. and Niendorf, T.
Abstract:Purpose: The aim of this study was to achieve millimeter spatial resolution sodium in vivo MRI of the human eye at 7 T using a dedicated six-channel transceiver array. We present a detailed description of the radiofrequency coil design, along with electromagnetic field and specific absorption ratio simulations, data validation, and in vivo application. Methods: Electromagnetic field and specific absorption ratio simulations were performed. Transmit field uniformity was optimized by using a multi-objective genetic algorithm. Transmit field mapping was conducted using a phase-sensitive method. An in vivo feasibility study was carried out with 3-dimensional density-adapted projection reconstruction imaging technique. Results: Measured transmit field distribution agrees well with the one obtained from simulations. The specific absorption ratio simulations confirm that the radiofrequency coil is safe for clinical use. Our radiofrequency coil is light and conforms to an average human head. High spatial resolution (nominal 1.4 and 1.0 mm isotropic) sodium in vivo images of the human eye were acquired within scan times suitable for clinical applications (∼ 10 min). Conclusions: Three most important eye compartments in the context of sodium physiology were clearly delineated in all of the images: the vitreous humor, the aqueous humor, and the lens. Our results provide encouragement for further clinical studies. The implications for research into eye diseases including ocular melanoma, cataract, and glaucoma are discussed.
Keywords:Equipment Design, Eye, Imaging Phantoms, Magnetic Resonance Imaging, Sodium
Source:Magnetic Resonance in Medicine
ISSN:0740-3194
Publisher:Wiley
Volume:80
Number:2
Page Range:672-684
Date:August 2018
Additional Information:Copyright © 2018 International Society for Magnetic Resonance in Medicine
Official Publication:https://doi.org/10.1002/mrm.27053
External Fulltext:View full text on external repository or document server
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library