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Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.

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Item Type:Article
Title:Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.
Creators Name:Sassi, Y. and Avramopoulos, P. and Ramanujam, D. and Grueter, L. and Werfel, S. and Giosele, S. and Brunner, A.D. and Esfandyari, D. and Papadopoulou, A.S and De Strooper, B. and Huebner, N. and Kumarswamy, R. and Thum, T. and Yin, X. and Mayr, M. and Laggerbauer, B. and Engelhardt, S.
Abstract:Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium. The microRNA-29 (miR-29) family has been found to prevent excess collagen expression in various organs, particularly through its function in fibroblasts. Here, we show that miR-29 promotes pathologic hypertrophy of cardiac myocytes and overall cardiac dysfunction. In a mouse model of cardiac pressure overload, global genetic deletion of miR-29 or antimiR-29 infusion prevents cardiac hypertrophy and fibrosis and improves cardiac function. Targeted deletion of miR-29 in cardiac myocytes in vivo also prevents cardiac hypertrophy and fibrosis, indicating that the function of miR-29 in cardiac myocytes dominates over that in non-myocyte cell types. Mechanistically, we found cardiac myocyte miR-29 to de-repress Wnt signaling by directly targeting four pathway factors. Our data suggests that, cell- or tissue-specific antimiR-29 delivery may have therapeutic value for pathological cardiac remodeling and fibrosis.
Keywords:Cardiac Hypertrophy, miRNAs
Source:Nature Communications
ISSN:2041-1723
Publisher:Nature Publishing Group (U.K.)
Volume:8
Number:1
Page Range:1614
Date:20 November 2017
Official Publication:https://doi.org/10.1038/s41467-017-01737-4
PubMed:View item in PubMed

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