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Structure of the human chromosome interaction network

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Item Type:Article
Title:Structure of the human chromosome interaction network
Creators Name:Sarnataro, S. and Chiariello, A.M. and Esposito, A. and Prisco, A. and Nicodemi, M.
Abstract:New Hi-C technologies have revealed that chromosomes have a complex network of spatial contacts in the cell nucleus of higher organisms, whose organisation is only partially understood. Here, we investigate the structure of such a network in human GM12878 cells, to derive a large scale picture of nuclear architecture. We find that the intensity of intra-chromosomal interactions is power-law distributed. Inter-chromosomal interactions are two orders of magnitude weaker and exponentially distributed, yet they are not randomly arranged along the genomic sequence. Intra-chromosomal contacts broadly occur between epigenomically homologous regions, whereas inter-chromosomal contacts are especially associated with regions rich in highly expressed genes. Overall, genomic contacts in the nucleus appear to be structured as a network of networks where a set of strongly individual chromosomal units, as envisaged in the 'chromosomal territory' scenario derived from microscopy, interact with each other via on average weaker, yet far from random and functionally important interactions.
Keywords:Cell Nucleus, Human Chromosomes, Human Genome
Source:PLoS ONE
ISSN:1932-6203
Publisher:Public Library of Science (U.S.A.)
Volume:12
Number:11
Page Range:e0188201
Date:15 November 2017
Official Publication:https://doi.org/10.1371/journal.pone.0188201
PubMed:View item in PubMed

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