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Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest

Item Type:Article
Title:Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest
Creators Name:Espinosa-Medina, I. and Jevans, B. and Boismoreau, F. and Chettouh, Z. and Enomoto, H. and Müller, T. and Birchmeier, C. and Burns, Alan J and Brunet, J.F.
Abstract:Most of the enteric nervous system derives from the "vagal" neural crest, lying at the level of somites 1-7, which invades the digestive tract rostro-caudally from the foregut to the hindgut. Little is known about the initial phase of this colonization, which brings enteric precursors into the foregut. Here we show that the "vagal crest" subsumes two populations of enteric precursors with contrasted origins, initial modes of migration, and destinations. Crest cells adjacent to somites 1 and 2 produce Schwann cell precursors that colonize the vagus nerve, which in turn guides them into the esophagus and stomach. Crest cells adjacent to somites 3-7 belong to the crest streams contributing to sympathetic chains: they migrate ventrally, seed the sympathetic chains, and colonize the entire digestive tract thence. Accordingly, enteric ganglia, like sympathetic ones, are atrophic when deprived of signaling through the tyrosine kinase receptor ErbB3, while half of the esophageal ganglia require, like parasympathetic ones, the nerve-associated form of the ErbB3 ligand, Neuregulin-1. These dependencies might bear relevance to Hirschsprung disease, with which alleles of Neuregulin-1 are associated.
Keywords:Enteric Nervous System, Neural Crest, Neuregulin1, Animals, Chickens, Mice
Source:Proceedings of the National Academy of Sciences of the United States of America
ISSN:0027-8424
Publisher:National Academy of Sciences (U.S.A.)
Volume:114
Number:45
Page Range:11980-11985
Date:7 November 2017
Official Publication:https://doi.org/10.1073/pnas.1710308114
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed

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