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Pregnancy-associated plasma protein-A2 and anthropometry, lifestyle, and biochemical factors in a human adult population

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Item Type:Article
Title:Pregnancy-associated plasma protein-A2 and anthropometry, lifestyle, and biochemical factors in a human adult population
Creators Name:Steinbrecher, A. and Janke, J. and Poy, M.N. and Oxvig, C. and Pischon, T.
Abstract:Pregnancy-associated plasma protein-A2 (PAPP-A2), a metalloproteinase purportedly related to pregnancy, foetal growth and development, has recently been described essential for pre-adult growth. Thus, we measured PAPP-A2 in plasma of a non-pregnant population and determined its associations with lifestyle, anthropometric or biochemical factors. In this cross-sectional study of 387 participants (20-70 years) randomly drawn from registration offices near Berlin, Germany, socio-economic and lifestyle factors were assessed by questionnaires, and anthropometric measures and blood samples were taken by trained personnel. Blood was analysed for standard clinical parameters. PAPP-A2 concentration was measured by ELISA. Generalized linear models were used to estimate associations with anthropometric and biochemical factors adjusted for age, sex, and weight. Adjusted mean PAPP-A2 concentration was slightly higher in women (283 pg/mL) than in men (261 pg/mL, p = 0.05) and positively correlated with age (r = 0.17, p = 0.001). PAPP-A2 concentration was inversely associated with body mass index (-2.7 pg/mL per kg/m(2), p = 0.03) and weight (-1.0 pg/mL per kg, p = 0.01) and positively associated with γ-glutamyl transferase (13.6 pg/mL per SD, p = 0.02), aspartate transaminase (18.5 pg/mL per SD, p = 0.002) and lactate dehydrogenase (14.9 pg/mL per SD, p = 0.02). Our results support that PAPP-A2, beyond its established role in early growth and development is relevant in adult metabolisms.
Keywords:Anthropometry, Berlin, Biomarkers, Cross-Sectional Studies, Life Style, Pregnancy, Pregnancy-Associated Plasma Protein-A, Public Health Surveillance, Risk Factors
Source:Scientific Reports
Publisher:Nature Publishing Group
Page Range:10455
Date:5 September 2017
Official Publication:https://doi.org/10.1038/s41598-017-10629-y
PubMed:View item in PubMed

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