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The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance

Item Type:Article
Title:The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance
Creators Name:Royla, N. and Kempa, S.
Abstract:Our recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 3' untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metabolic targeting of glutamine metabolism.
Keywords:Drug Resistance, Cancer Metabolism, Glutamine, Post-Transcriptional Regulation
Source:Molecular & Cellular Oncology
ISSN:2372-3556
Publisher:Taylor & Francis (U.S.A.)
Volume:4
Number:4
Page Range:e1338209
Date:5 July 2017
Additional Information:Copyright © 2017 Max Delbrück Center for Molecular Medicine
Official Publication:https://doi.org/10.1080/23723556.2017.1338209
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed

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