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Renin-angiotensin system in diabetes

Item Type:Review
Title:Renin-angiotensin system in diabetes
Creators Name:Rein, J. and Bader, M.
Abstract:The renin-angiotensin system (RAS) has two different axes, the classical one with the effector peptide angiotensin II and the new one with the effector peptide angiotensin (1-7). Both peptides have been shown to be involved in the pathogenesis of diabetes mellitus and its consequences, nephropathy, retinopathy and cardiomyopathy in animal models and patients. In diabetes, angiotensin II acts mostly deleterious and angiotensin (1-7) protective. In this review we summarize the knowledge about the role of the different RAS axes in diabetes mellitus and the use of drugs interfering with the RAS in the therapy of the disease.
Keywords:Renin-angiotensin system, Effector Peptide angiotensin, Pathogenesis, Diabetes Mellitus, Drugs, Therapy, Animals
Source:Protein and Peptide Letters
Publisher:Bentham (United Arab Emirates)
Page Range:833-840
Date:17 November 2017
Official Publication:https://doi.org/10.2174/0929866524666170728144357
PubMed:View item in PubMed

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