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How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency

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Item Type:Article
Title:How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency
Creators Name:Römer, C. and Singh, M. and Hurst, L.D. and Izsvák, Z.
Abstract:HERVH is one of the most successful endogenous retrovirus in the human genome. Relative to other endogenous retroviruses, slower degradation of HERVH internal sequences indicates their potential relevance for the host. HERVH is transcriptionally active during human preimplantation embryogenesis. In this review, we focus on the role of HERVH in regulating human pluripotency. The HERVH-mediated pluripotency network has been evolved recently in primates. Nevertheless, it became an essential feature of human pluripotency. We discuss how HERVH modulates the human pluripotency network by providing alternative transcription factor binding sites, functioning as a long-range enhancer, and as being a major source for pluripotency specific long non-coding RNAs and chimeric transcripts.
Keywords:DNA Transposable Elements, Embryonic Development, Endogenous Retroviruses, Evolution, Molecular, Gene Expression Regulation, Viral, Genome, Human, Pluripotent Stem Cells, RNA, Long Noncoding, Transcription Factors, Transcriptional Activation, Animals, Primates
Source:Current Opinion in Virology
ISSN:1879-6257
Publisher:Elsevier
Volume:25
Page Range:49-58
Date:August 2017
Additional Information:Copyright © 2017, Elsevier. Erratum in: Curr Opin Virol 2020-04-04 (in Press)
Official Publication:https://doi.org/10.1016/j.coviro.2017.07.001
PubMed:View item in PubMed

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