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BMP signaling regulates satellite cell dependent postnatal muscle growth

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Item Type:Article
Title:BMP signaling regulates satellite cell dependent postnatal muscle growth
Creators Name:Stantzou, A. and Schirwis, E. and Swist, S. and Alonso-Martin, S. and Polydorou, I. and Zarrouki, F. and Mouisel, E. and Beley, C. and Julien, A. and Le Grand, F. and Garcia, L. and Colnot, C. and Birchmeier, C. and Braun, T. and Schuelke, M. and Relaix, F. and Amthor, H.
Abstract:Postnatal growth of skeletal muscle largely depends on the expansion and differentiation of resident stem cells, the so-called satellite cells. Here we demonstrate that postnatal satellite cells express components of the Bone Morphogenetic Protein (BMP) signaling machinery. Overexpression of Noggin in postnatal mice, to antagonize BMP ligands, or satellite cell specific knock-out of BMP transmembrane receptor Alk3, or overexpression of inhibitory SMAD6 decreased satellite cell proliferation and accretion during myofiber growth and ultimately retarded muscle growth. Moreover, reduced BMP signaling diminished the adult satellite cell pool. Abrogation of BMP signaling in satellite cell-derived primary myoblasts strongly diminished cell proliferation and up-regulated the expression of cell cycle inhibitors p21 and p57 In conclusion, these results show that BMP signaling defines postnatal muscle development by regulating satellite cell dependent myofiber growth and the generation of the adult muscle stem cell pool.
Keywords:BMP Signaling, Postnatal Muscle Growth, Satellite Cells, Muscle Stem Cells, Animals, Mice
Publisher:Company of Biologists
Page Range:2737-2747
Date:1 August 2017
Additional Information:Copyright © 2017 The Authors. Published by The Company of Biologists Ltd.
Official Publication:https://doi.org/10.1242/dev.144089
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed

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